Synthesis and antitumor-evaluation of 1,3,4-thiadiazole-containing benzisoselenazolone derivatives

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• 作者：Zhenhua Luo ; Baoquan Chen ; ^{chenbaoquan6@yahoo.com.cn} ; Shuangyan He ; Yanping Shi ; Yuming Liu ; Caiwen Li
• 关键词：Benzisoselenazolone derivatives ; 1 ; 3 ; 4-Thiadiazole ; Antitumor agents
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2012
• 出版时间：1 May, 2012
• 年：2012
• 卷：22
• 期：9
• 页码：3191-3193
• 全文大小：279 K

文摘

A series of novel 1,3,4-thiadiazole-containing benzisoselenazolone derivatives were prepared by the condensation of 2-chloroselenobenzoyl chloride and 2-amino-5-substituted-1,3,4-thiadiazole. Their in vitro antiproliferative activities were evaluated in SSMC-7721, MCF-7 and A-549 cells. The results suggest that, in different tumor cells, some compounds have good antiproliferative activity, certain selectivity and potential value of further research.