Brucella abortusΔcydCΔcydD and ΔcydCΔpurD double-mutants are highly attenuated and confer long-term protective immunity against virulent Brucella abortus
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- 作者：Quang Lam Truong ; Youngjae Cho ; Soyeon Park ; Kiju Kim ; Tae-Wook Hahn ; twhahn@kangwon.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Brucella abortus ; Live attenuated vaccine ; Attenuation ; Immune response ; Protection
- 刊名：Vaccine
- 出版年：2016
- 出版时间：4 January 2016
- 年：2016
- 卷：34
- 期：2
- 页码：237-244
- 全文大小：1887 K
文摘
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BA15ΔcydC, ΔcydD, ΔcydCΔcydD, ΔcydCΔpurD mutants are attenuated in vitro and vivo.
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BA15 mutants are able to induce robust humoral and cell-mediated immune responses.
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BA15 mutants are able to induce long-term protective immunity in mice.
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BA15 mutants deserve further investigations in cattle against bovine brucellosis.
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