Non-canonical GLI1/2 activation by PI3K/AKT signaling in renal cell carcinoma: A novel potential therapeutic target
详细信息 查看全文
- 作者：Jiancheng Zhoua ; 1 ; Guodong Zhua ; 1 ; Jun Huanga ; Lei Lia ; Yuefeng Dua ; Yang Gaoa ; Dapeng Wua ; Xinyang Wanga ; Jer-Tsong Hsiehb ; Dalin Hea ; dalinhe@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Kaijie Wua ; kaijie_wu@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Renal cell carcinoma ; Hedgehog pathway ; VHL ; PI3K/AKT ; Therapeutic target
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：28 January 2016
- 年：2016
- 卷：370
- 期：2
- 页码：313-323
- 全文大小：4941 K
文摘
- •
GLI1 and GLI2 are aberrantly activated in ccRCC and associated with poor survival of patients.
- •
GLI1 and GLI2 are activated by the PI3K/AKT pathway via a SMO- and VHL-independent manner in ccRCC.
- •
Simultaneously targeting GLIs and AKT pathways exhibits very potent efficacy to suppress tumor growth of ccRCC.
© 2004-2018 中国地质图书馆版权所有 京ICP备05064691号 京公网安备11010802017129号 地址：北京市海淀区学院路29号 邮编：100083 电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700 |