Cassane Diterpenoids from the Pericarps of Caesalpinia bonduc

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• 作者：Panpan Zhang ; Chunping Tang ; Sheng Yao ; Changqiang Ke ; Ge Lin ; Hui-Ming Hua ; Yang Ye
• 刊名：Journal of Natural Products
• 出版年：2016
• 出版时间：January 22, 2016
• 年：2016
• 卷：79
• 期：1
• 页码：24-29
• 全文大小：255K
• ISSN：1520-6025

文摘

Ten new cassane-type diterpenoids, caesalbonducins D–F (1–3), 6-deacetoxybonducellpin B (4), 3-acetoxy-α-caesalpin (5), 2(3)-en-α-caesalpin (6), 1α-hydroxycaesalpinin J (7), 1α-hydroxy-6-decaetoxysalpinin J (8), 6α-hydroxycaesall M (9), and 6α-hydroxy-14(17)-dehydrocaesalpin F (10), along with eight known compounds (11–18), were isolated from the pericarps of Caesalpinia bonduc. Compounds 1–3 and 11 are methyl-migrated cassane-type diterpenoids with a 19(4→3)-cassane skeleton. The structures of 1–10 were elucidated on the basis of 1D and 2D NMR methods and other spectroscopic analysis. The neuroprotective effects of the isolated compounds were evaluated.