Synthetic Entries to and Biological Activity of Pyrrolopyrimidines

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• 作者：Laurens M. De Coen ; Thomas S. A. Heugebaert ; Daniel García ; Christian V. Stevens
• 刊名：Chemical Reviews
• 出版年：2016
• 出版时间：January 13, 2016
• 年：2016
• 卷：116
• 期：1
• 页码：80-139
• 全文大小：4494K
• ISSN：1520-6890

文摘

This review summarizes recent literature (2000–2015) on the synthesis and pharmaceutical properties of pyrrolopyrimidines. These modified pyrimidine bases, fused to a pyrrole ring, and their corresponding nucleosides display a broad applicability in medicinal chemistry. This overview is divided into three main sections, according to the respective isomers: pyrrolo[2,3-d]pyrimidines, pyrrolo[3,2-d]pyrimidines, and pyrrolo[3,4-d]pyrimidines. Each section contains a description of common retro-synthetic strategies, with particular attention for newly reported synthetic entries to the scaffold. Next, the synthetic strategies and the ways in which the scaffolds can be further modified are exemplified according to the biological properties of the obtained products.