Enantioselective Hydrogenation of N−H Imines

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• 作者：Guohua Hou ; Francis Gosselin ; Wei Li ; J. Christopher McWilliams ; Yongkui Sun ; Mark Weisel ; Paul D. O’ ; Shea ; Cheng-yi Chen ; Ian W. Davies ; Xumu Zhang
• 刊名：Journal of the American Chemical Society
• 出版年：2009
• 出版时间：July 29, 2009
• 年：2009
• 卷：131
• 期：29
• 页码：9882-9883
• 全文大小：109K
• 年卷期：v.131,no.29(July 29, 2009)
• ISSN：1520-5126

文摘

N−H ketoimines 3a−3v are readily prepared in high yield via organometallic addition to nitriles and isolated as corresponding bench-stable hydrochloride salts. Homogeneous asymmetric hydrogenation of unprotected N−H ketoimines 3a−3v using Ir-(S,S)-f-binaphane as catalyst provides chiral amines 4a−4v in 90−95% yield with enantioselectivities up to 95% ee.