Subcellular Neural Probes from Single-Crystal Gold Nanowires

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• 作者：Mijeong Kang ; Seungmoon Jung ; Huanan Zhang ; Taejoon Kang ; Hosuk Kang ; Youngdong Yoo ; Jin-Pyo Hong ; Jae-Pyoung Ahn ; Juhyoun Kwak ; Daejong Jeon ; Nicholas A. Kotov ; Bongsoo Kim
• 刊名：ACS Nano
• 出版年：2014
• 出版时间：August 26, 2014
• 年：2014
• 卷：8
• 期：8
• 页码：8182-8189
• 全文大小：529K
• ISSN：1936-086X

文摘

Size reduction of neural electrodes is essential for improving the functionality of neuroprosthetic devices, developing potent therapies for neurological and neurodegenerative diseases, and long-term brain鈥揷omputer interfaces. Typical neural electrodes are micromanufactured devices with dimensions ranging from tens to hundreds of micrometers. Their further miniaturization is necessary to reduce local tissue damage and chronic immunological reactions of the brain. Here we report the neural electrode with subcellular dimensions based on single-crystalline gold nanowires (NWs) with a diameter of 鈭?00 nm. Unique mechanical and electrical properties of defect-free gold NWs enabled their implantation and recording of single neuron-activities in a live mouse brain despite a 鈭?0脳 reduction of the size compared to the closest analogues. Reduction of electrode dimensions enabled recording of neural activity with improved spatial resolution and differentiation of brain activity in response to different social situations for mice. The successful localization of the epileptic seizure center was also achieved using a multielectrode probe as a demonstration of the diagnostics potential of NW electrodes. This study demonstrated the realism of single-neuron recording using subcellular-sized electrodes that may be considered a pivotal point for use in diverse studies of chronic brain diseases.

Keywords:

gold nanowire; nanoelectrode; neural implants; neuroprosthetics; brain鈭抦achine interface; neurodegenerative disease; epilepsy; subcellular-sized implants; BRAIN initiative; single-neuron detection; electrode miniaturization; long-term neural recordings; paralysis