Highly (E)-Selective Wadsworth−Emmons Reactions Promoted by Methylmagnesium Bromide

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• 作者：Timothy D. W. Claridge ; Stephen G. Davies ; James A. Lee ; Rebecca L. Nicholson ; Paul M. Roberts ; Angela J. Russell ; Andrew D. Smith ; Steven M. Toms
• 刊名：Organic Letters
• 出版年：2008
• 出版时间：December 4, 2008
• 年：2008
• 卷：10
• 期：23
• 页码：5437-5440
• 全文大小：188K
• 年卷期：v.10,no.23(December 4, 2008)
• ISSN：1523-7052

文摘

An experimentally simple protocol for the very highly (E)-selective Wadsworth−Emmons reaction [(E):(Z) selectivities in excess of 180:1 in some cases] of a range of straight-chain and branched aliphatic, substituted aromatic, and base-sensitive aldehydes via reaction with an alkyl diethylphosphonoacetate and MeMgBr is reported.