Cobalt(II) and Cobalt(III) Dipicolinate Complexes: Solid State, Solution, and in Vivo Insulin-like Properties
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- 作者：Luqin Yang ; Debbie C. Crans ; Susie M. Miller ; Agnete la Cour ; Oren P. Anderson ; Peter M. Kaszynski ; Michael E. Godzala ; III ; LaTanya D. Austin ; and Gail R. Willsky
- 刊名：Inorganic Chemistry
- 出版年：2002
- 出版时间：September 23, 2002
- 年：2002
- 卷：41
- 期：19
- 页码：4859 - 4871
- 全文大小：219K
- 年卷期：v.41,no.19(September 23, 2002)
- ISSN：1520-510X
文摘
The synthesis and characterization of Co(II) and Co(III) 2,6-pyridinedicarboxylate (dipic2-) complexes are reported.Solid-state X-ray characterizations were performed on [Co(H2dipic)(dipic)]·3H2O and [Co(dipic)(
-dipic)Co(H2O)5]·2H2O. Two coordination modes not previously observed in dipicolinate transition metal complexes were observedin these complexes; one involves metal coordination to the short C-O (C=O) bond, and the other involves metalcoordination to a protonated oxygen atom. Solution studies, including paramagnetic NMR and UV-vis spectroscopy,were done showing the high stability and low lability of the Co(III) complex, whereas the Co(II) complexes exhibitedligand exchange in the presence of excess ligand. The [Co(dipic)2]2- complex has pH dependent lability and in thisregard is most similar to the [VO2dipic]- complex. The [Co(dipic)2]2- was found to be effective in reducing thehyperlipidemia of diabetes using oral administration in drinking water in rats with STZ-induced diabetes. Oraladministration of VOSO4 was used as a positive control for metal efficacy against diabetes. In addition to providinga framework to evaluate structure-function relationships of various transition metal complexes in alleviating thesymptoms of diabetes, this work describes novel aspects of structural and solution cobalt chemistry.
-dipic)Co(H2O)5]·2H2O. Two coordination modes not previously observed in dipicolinate transition metal complexes were observedin these complexes; one involves metal coordination to the short C-O (C=O) bond, and the other involves metalcoordination to a protonated oxygen atom. Solution studies, including paramagnetic NMR and UV-vis spectroscopy,were done showing the high stability and low lability of the Co(III) complex, whereas the Co(II) complexes exhibitedligand exchange in the presence of excess ligand. The [Co(dipic)2]2- complex has pH dependent lability and in thisregard is most similar to the [VO2dipic]- complex. The [Co(dipic)2]2- was found to be effective in reducing thehyperlipidemia of diabetes using oral administration in drinking water in rats with STZ-induced diabetes. Oraladministration of VOSO4 was used as a positive control for metal efficacy against diabetes. In addition to providinga framework to evaluate structure-function relationships of various transition metal complexes in alleviating thesymptoms of diabetes, this work describes novel aspects of structural and solution cobalt chemistry.© 2004-2018 中国地质图书馆版权所有 京ICP备05064691号 京公网安备11010802017129号 地址：北京市海淀区学院路29号 邮编：100083 电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700 |