Two Pairs of Enantiomeric Alkaloid Dimers from Macleaya cordata

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• 作者：Chun-Mei Sai ; Da-Hong Li ; Chun-Mei Xue ; Kai-Bo Wang ; Ping Hu ; Yue-Hu Pei ; Jiao Bai ; Yong-Kui Jing ; Zhan-Lin Li ; Hui-Ming Hua
• 刊名：Organic Letters
• 出版年：2015
• 出版时间：August 21, 2015
• 年：2015
• 卷：17
• 期：16
• 页码：4102-4105
• 全文大小：312K
• ISSN：1523-7052

文摘

Two pairs of enantiomeric alkaloid dimers, (卤)-macleayins A (1) and B (2), representing a novel dimerization pattern of two different types of alkaloids via a C鈥揅 蟽-bond, were isolated from the aerial parts of Macleaya cordata. The enantiomeric separation was achieved by chiral chromatography. Their structures and stereochemistry were determined by the analysis of extensive spectroscopic data, electronic circular dichroism calculation, and single-crystal X-ray diffraction data. (鈭?-Macleayin A exhibits modest cytotoxic activity against HL-60 cell line with the IC₅₀ value of 3.51 渭M.