Benzosceptrins A and B with a Unique Benzocyclobutane Skeleton and Nagelamide S and T from Pacific Sponges

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• 作者：Jrme Appenzeller ; Supriya Tilvi ; Marie-Thrse Martin ; Jean-Franois Gallard ; Hoda El-bitar ; Elise Tran Huu Dau ; Ccile Debitus ; Dominique Laurent ; Cline Moriou ; Ali Al-Mourabit
• 刊名：Organic Letters
• 出版年：2009
• 出版时间：November 5, 2009
• 年：2009
• 卷：11
• 期：21
• 页码：4874-4877
• 全文大小：248K
• 年卷期：v.11,no.21(November 5, 2009)
• ISSN：1523-7052

文摘

Four new dimeric pyrrole-2-aminoimidazole alkaloids have been isolated from the Pacific marine sponges Agelas cf. mauritiana and Phakellia sp. They include the unusual C2 symmetrical benzosceptrins A (4) and B (5), which each possess a unique benzocyclobutane skeleton and nagelamides S (6) and T (7). Their structures and relative configuration were elucidated from spectroscopic data. Plausible biogenetic paths for these compounds are also proposed in this paper.