On the Mode of Action of N-Phenyl-2-naphthylamine in Plants

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• 作者：Rolf Altenburger ; Werner Brack ; William R. Greco ; Matthias Grote ; Klaus Jung ; Agnes Ovari ; Janet Riedl ; Katrin Schwab ; Eberhard Kü ; ster
• 刊名：Environmental Science & Technology
• 出版年：2006
• 出版时间：October 1, 2006
• 年：2006
• 卷：40
• 期：19
• 页码：6163 - 6169
• 全文大小：127K
• 年卷期：v.40,no.19(October 1, 2006)
• ISSN：1520-5851

文摘

N-phenyl-2-naphthylamine, a sediment contaminantpreviously identified as a major toxicant of site-specificimportance was investigated for its mode of toxic action.From short-term bioassays with daphnids, fish eggs, bacteria,and algae it appears that this compound has specificphytotoxic properties at concentrations below 100 g/L,which cannot be explained assuming an unspecific narcosistype of action in plants. Also, hydroxy-, nitro-, and methyl-derivatives show clear excess toxicity as compared tobaseline toxic effects. Of several plant-specific growth anddevelopment processes investigated, only photosynthesiscould be demonstrated to be affected at short exposure timesand low concentrations. Disturbance of primary photosynthetic reactions such as oxygen evolution and fluorescencequenching, however, becomes only apparent after 2-3 hof exposure, which is in sharp contrast to known specificinhibitors targeting processes such as electron transportor ATP production. This, and concentration-time-effectmodeling lead to the suggestion that N-phenyl-2-naphthylamine acts intracellular as a reactive compoundin cell membranes producing irreversible, and thus cumulative,damage over time in algae. The effects may becomefirst apparent in membrane-rich compartments such asthe algal chloroplast.