Compositional Analysis and Preliminary Toxicological Evaluation of a Tea Polysaccharide Conjugate

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• 作者：Haixia Chen ; Min Zhang ; Zhishuang Qu ; Bijun Xie
• 刊名：Journal of Agricultural and Food Chemistry
• 出版年：2007
• 出版时间：March 21, 2007
• 年：2007
• 卷：55
• 期：6
• 页码：2256 - 2260
• 全文大小：61K
• 年卷期：v.55,no.6(March 21, 2007)
• ISSN：1520-5118

文摘

Tea polysaccharide conjugate is one of the main bioactive constituents of tea (Camellia sinensis L.).The chemical composition and preliminary toxicological evaluation of a tea polysaccharide conjugatewas investigated to determine the possibility of using it for human consumption. Chemical analysisof tea polysaccharide conjugate showed that the tea polysaccharide conjugate was a nonstarch proteinbounded acidic polysaccharide. The protein, neutral sugar, and uronic acid content of the teapolysaccharide conjugate was 3.5%, 44.2%, and 43.1%, respectively. The contents of iron,magnesium, zinc, and selenium in the tea and its polysaccharide conjugate were measured byinductively coupled plasma-optical emission spectrometry (ICP-OES). Results showed that thecontents of four elements in tea polysaccharide conjugate were much higher than that of tea power.Especially, the content of iron in tea polysaccharide conjugate was increased 5.9 times. The teapolysaccharide conjugate, when fed to mice, was found to have no toxicity to the liver, kidney, heart,thymus, or spleen of the mice and none of the mice died throughout the period of the experiment.There was no significant difference between the thymus index, spleen index, and liver index of themice from the test and control groups (P > 0.05). On the basis of the study, the tea polysaccharideconjugate may be classified either as a very low toxicity substance, that is, GHS Category 5 (globallyharmonized system), or as unclassified when orally administrated to mice. It might be a candidate ofdietary supplements besides the bioactivities as a polysaccharide.