Design of a Highly Sensitive and Specific Nucleotide Sensor Based on Photon Upconverting Particles

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• 作者：Peng Zhang ; Snezna Rogelj ; Khoi Nguyen ; Damon Wheeler
• 刊名：Journal of the American Chemical Society
• 出版年：2006
• 出版时间：September 27, 2006
• 年：2006
• 卷：128
• 期：38
• 页码：12410 - 12411
• 全文大小：53K
• 年卷期：v.128,no.38(September 27, 2006)
• ISSN：1520-5126

文摘

We have designed and developed a novel sensor that reports the presence of specific nucleic acids in solutions, based on photon upconverting particles. The significantly high signal-to-noise ratio of photon upconverting particles leads to high sensitivity of the sensor. The sensor does not suffer from photobleaching. It also displays high specificity and self-calibrating capability. We expect nucleotide sensors of this type to be effective for applications in both DNA/RNA detection and protein-DNA/RNA interaction studies.