Transition Metal-Catalyzed Orthogonal Solid-Phase Decoration of the 2(1H)-Pyrazinone Scaffold Using a Sulfur Linker

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• 作者：Nadya Kaval ; Brajendra Kumar Singh ; Denis S. Ermolat'ev ; Stijn Claerhout ; Virinder S. Parmar ; Johan Van der Eycken ; Erik Van der Eycken
• 刊名：Journal of Combinatorial Chemistry
• 出版年：2007
• 出版时间：May 2007
• 年：2007
• 卷：9
• 期：3
• 页码：446 - 453
• 全文大小：215K
• 年卷期：v.9,no.3(May 2007)
• ISSN：1520-4774

文摘

A new transition metal-catalyzed orthogonal solid-phase protocol for the synthesis of highly substituted2(1H)-pyrazinones was developed, on the basis of Chan-Lam arylation and Liebeskind-Srogl cross-couplingreactions. This strategy opens the way for the generation of small libraries of 2(1H)-pyrazinone analoguesfor biological screening.