Unusual Naphthoquinone Derivatives from the Twigs of Avicennia marina

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• 作者：Li Han ; Xueshi Huang ; Hans-Martin Dahse ; Ute Moellmann ; Hongzheng Fu ; Susanne Grabley ; Isabel Sattler ; Wenhan Lin
• 刊名：Journal of Natural Products
• 出版年：2007
• 出版时间：June 2007
• 年：2007
• 卷：70
• 期：6
• 页码：923 - 927
• 全文大小：91K
• 年卷期：v.70,no.6(June 2007)
• ISSN：1520-6025

文摘

In a continuing search for novel bioactive compounds from marine mangrove plants, seven new naphthoquinone derivativeswere isolated from Avicennia marina, namely, avicennone A (1), avicennone B (2), avicennone C (3), avicennone D(4), avicenone E (5), avicennone F (6), and avicennone G (7), along with the known compounds avicequinone A (8),stenocarpoquinone B (9), avicequinone C (10), avicenol A (11), and avicenol C (12). The chemical structures of 1-7were elucidated by spectroscopic methods. Compounds 8-10, and a mixture of 4 and 5, which all contain a 4,9-dionegroup, showed strong antiproliferative and moderate cytotoxic activities, as well as antibacterial effects.