Bioactive Guaianolides from Siyekucai (Ixeris chinensis)

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• 作者：Shujun Zhang ; Ming Zhao ; Liming Bai ; Toshiaki Hasegawa ; Jinlan Wang ; Liyan Wang ; Hongyan Xue ; Qigang Deng ; Fenglan Xing ; Yuhua Bai ; Jun-ichi Sakai ; Jiao Bai ; Rei Koyanagi ; Yoshinori Tsukumo ; Takao Ka
• 刊名：Journal of Natural Products
• 出版年：2006
• 出版时间：October 2006
• 年：2006
• 卷：69
• 期：10
• 页码：1425 - 1428
• 全文大小：64K
• 年卷期：v.69,no.10(October 2006)
• ISSN：1520-6025

文摘

Two new guaianolides, named chinensiolides D (5) and E (6), were isolated from Ixeris chinensis Nakai, and theirstructures were determined to be 10-hydroxy-3-oxoguaia-11(13)-eno-12,6-lactone (5) and 10-hydroxy-3-O-[2,6-di(p-hydroxyphenylacetyl)--glucopylanosyl]guaia-4(15),11(13)-dieno-12,6-lactone (6). The first isolation of (11S)-10-hydroxy-3-oxoguaia-4-eno-12,6-lactone (4) from natural sources and its characterization are also reported.Chinenciolide E (6) showed significant growth inhibitory activity toward VA-13 malignant lung tumor cells (IC₅₀ =0.72 M).