The Palladium-Catalyzed Addition of Aryl- and Heteroarylboronic Acids to Aldehydes

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• 作者：Changming Qin ; Huayue Wu ; Jiang Cheng ; Xi'an Chen ; Miaochang Liu ; Weiwei Zhang ; Weike Su ; Jinchang Ding
• 刊名：Journal of Organic Chemistry
• 出版年：2007
• 出版时间：May 25, 2007
• 年：2007
• 卷：72
• 期：11
• 页码：4102 - 4107
• 全文大小：129K
• 年卷期：v.72,no.11(May 25, 2007)
• ISSN：1520-6904

文摘

Reaction of aryl- or heteroarylboronic acids with aldehydes, in the presence of PdCl₂ and P(1-Nap)₃,afforded carbinol derivatives in good to excellent yields. The efficiency of this reaction was demonstratedby the compatibility with nitro, cyano, acetamido, acetoxy, acetyl, carboxyl, trifluoromethyl, fluoro, andchloro groups and the possibility of involving aliphatic aldehyde or hindered substrates. Moreover, therigorous exclusion of air/moisture is not required in these transformations.