Selective Synthesis of 2,3-Disubstituted-2H-isoindol-1-ylphosphonate and 2,3-Disubstituted-1,2-dihydroiso- quinolin-1-ylphosphonate via Metal-Tuned Reaction of 详细信息    查看全文

• 作者：Qiuping Ding ; Yang Ye ; Renhua Fan ; Jie Wu
• 刊名：Journal of Organic Chemistry
• 出版年：2007
• 出版时间：July 6, 2007
• 年：2007
• 卷：72
• 期：14
• 页码：5439 - 5442
• 全文大小：80K
• 年卷期：v.72,no.14(July 6, 2007)
• ISSN：1520-6904

文摘

Palladium(II)-catalyzed reaction of -amino (2-alkynylphenyl)methylphosphonate provides a novel and efficient routeto 2,3-disubstituted-2H-isoindol-1-ylphosphonate via 5-exo-cyclization and [1,5]-H shift; while 2,3-disubstituted-1,2-dihydroisoquinolin-1-ylphosphonate is afforded through 6-endo-cyclization utilizing silver triflate as catalyst.