A Mild and Efficient Synthesis of 4-Quinolones and Quinolone Heterocycles

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• 作者：Daniel Zewge ; Cheng-yi Chen ; Curtis Deer ; Peter G. Dormer ; Dave L. Hughes
• 刊名：Journal of Organic Chemistry
• 出版年：2007
• 出版时间：May 25, 2007
• 年：2007
• 卷：72
• 期：11
• 页码：4276 - 4279
• 全文大小：89K
• 年卷期：v.72,no.11(May 25, 2007)
• ISSN：1520-6904

文摘

The cycloacylation of aniline derivatives to 4-quinolones inthe presence of Eaton's reagent is described. This high-yielding methodology is applicable to a wide variety offunctionalized anilines and requires milder conditions thanthose traditionally employed. This cyclization protocol isused to prepare a host of heterocycles and bis-quinolonesand is characterized by relatively low reaction temperatureand ease of product isolation.