Telluroxides Exhibit Hydrolysis Capacity

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• 作者：Zeyuan Dong ; Xiangqiu Li ; Kai Liang ; Shizhong Mao ; Xin Huang ; Bing Yang ; Jiayun Xu ; Junqiu Liu ; Guimin Luo ; Jiacong Shen ; J. Shen
• 刊名：Journal of Organic Chemistry
• 出版年：2007
• 出版时间：January 19, 2007
• 年：2007
• 卷：72
• 期：2
• 页码：606 - 609
• 全文大小：245K
• 年卷期：v.72,no.2(January 19, 2007)
• ISSN：1520-6904

文摘

It has long been known that tellurium compounds are rather toxic to living organisms, and tellurium hasnot been found in natural biomacromolecules to date. The principles of telluride toxicity in biologicalprocesses are still controversial partly because of the lack of information on the biochemical features oftellurium. In this contribution, we report our finding for the first time that telluroxides exhibit hydrolysiscapacity. For instance, 6,6'-telluroxy-bis(6-deoxy--cyclodextrin) acts as a hydrolase mimic and showsa significant rate acceleration of 106 000 for the hydrolysis of 4,4'-dinitrodiphenyl carbonate.