Protein鈥揚rotein Interface Mimicry by an Oxazoline Piperidine-2,4-dione

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• 作者：Xun Li ; Jaru Taechalertpaisarn ; Dongyue Xin ; Kevin Burgess
• 刊名：Organic Letters
• 出版年：2015
• 出版时间：February 6, 2015
• 年：2015
• 卷：17
• 期：3
• 页码：632-635
• 全文大小：348K
• ISSN：1523-7052

文摘

Representative minimalist mimics 1 were prepared from amino acids. Scaffold 1 was not designed to mimic any particular secondary structure, but simulated accessible conformations of this material were compared with common ideal secondary structures and with >125000 different protein鈥損rotein interaction (PPI) interfaces. This data mining exercise indicates that scaffolds 1 can mimic features of sheet-turn-sheets, somewhat fewer helical motifs, and numerous PPI interface regions that do not resemble any particular secondary structure.