Poly(2-oxazoline)-Based Nanogels as Biocompatible Pseudopolypeptide Nanoparticles

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• 作者：Camille Legros ; Anne-Laure Wirotius ; Marie-Claire De Pauw-Gillet ; Kam Chiu Tam ; Daniel Taton ; S茅bastien Lecommandoux
• 刊名：Biomacromolecules
• 出版年：2015
• 出版时间：January 12, 2015
• 年：2015
• 卷：16
• 期：1
• 页码：183-191
• 全文大小：465K
• ISSN：1526-4602

文摘

Hydrophilic nanogels based on partially hydrolyzed poly(2-ethyl-2-oxazoline) were synthesized in dilute aqueous media in the presence of 1,6-hexanediol diglycidyl ether as a cross-linker. Nanogel formation was monitored by DLS and HSQC NMR spectroscopy, and the final nano-objects were characterized by DLS, TEM, AFM, and NanoSight analyses. Nanogels with a hydrodynamic radius of 78 nm exhibiting a slight positive surface charge were obtained. MTS assays (cell metabolic activity test) evidenced that nanogels were nontoxic in the investigated concentration range (i.e., 0.1 to 400 渭g/mL) and that no specific interaction with bovine serum albumin was observed.