Enantioselective Synthesis of 2-Amino Acids via Rh-Catalyzed Asymmetric Hydrogenation with BoPhoz-Type Lig

详细信息    查看全文

• 作者：Jun Deng ; Xiang-Ping Hu ; Jia-Di Huang ; Sai-Bo Yu ; Dao-Yong Wang ; Zheng-Chao Duan ; Zhuo Zheng
• 刊名：Journal of Organic Chemistry
• 出版年：2008
• 出版时间：March 7, 2008
• 年：2008
• 卷：73
• 期：5
• 页码：2015 - 2017
• 全文大小：72K
• 年卷期：v.73,no.5(March 7, 2008)
• ISSN：1520-6904

文摘

A series of BoPhoz-type ligands were successfully appliedin the rhodium-catalyzed asymmetric hydrogenation of anumber of -substituted or unsubstituted -(phthalimidomethyl)acrylates, affording good to excellent enantioselectivities. The results suggested that the presence of an N-Hproton in the BoPhoz backbone could significantly improvethe enantioselectivity, and ligand (S_c,R_p)-1d, bearing two CF₃-groups in the 3,5-position of the phenyl ring of aminophosphino moiety, showed the highest enantioselectivity.