Readily Available Chiral Phosphine-Aminophosphine Ligands for Highly Efficient Rh-Catalyzed Asymmetric Hydrogenation of -Enol Ester

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• 作者：Dao-Yong Wang ; Jia-Di Huang ; Xiang-Ping Hu ; Jun Deng ; Sai-Bo Yu ; Zheng-Chao Duan ; Zhuo Zheng
• 刊名：Journal of Organic Chemistry
• 出版年：2008
• 出版时间：March 7, 2008
• 年：2008
• 卷：73
• 期：5
• 页码：2011 - 2014
• 全文大小：70K
• 年卷期：v.73,no.5(March 7, 2008)
• ISSN：1520-6904

文摘

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A new class of unsymmetrical hybrid phosphine-aminophosphine ligands has been prepared from commerciallyavailable, inexpensive (S)-1-phenylethylamine through aconcise synthetic procedure. These ligands are not verysensitive to air and moisture, and displayed good enantioselectivities in the Rh-catalyzed asymmetric hydrogenation ofvarious dimethyl -benzoyloxyethenephosphonates bearing-aryl, -alkyl, and -alkoxy substituents and N-benzyloxycarbonyl -enamido phosphonates, in which up to 97% eewas obtained. A side-by-side comparison study disclosed thatthese new phosphine-aminophosphine ligands showed betterenantioselectivity than BoPhoz ligands.