Microwave-Assisted Combinatorial Synthesis of Polysubstituent Imidazo[1,2-a]quinoline, Pyrimido[1,2-a]quinoline and Quinolino[1,2-a]quinazoline Derivatives

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• 作者：Shujiang Tu ; Chunmei Li ; Guigen Li ; Longji Cao ; Qingqing Shao ; Dianxiang Zhou ; Bo Jiang ; Jianfeng Zhou ; Min Xia
• 刊名：Journal of Combinatorial Chemistry
• 出版年：2007
• 出版时间：November 2007
• 年：2007
• 卷：9
• 期：6
• 页码：1144 - 1148
• 全文大小：107K
• 年卷期：v.9,no.6(November 2007)
• ISSN：1520-4774

文摘

A series of unusual fused heterocyclic compound derivatives, consisting of a pyridine and a imidazole or pyrimidine core, with a bridgehead nitrogen, were successfully synthesized by a microwave-assisted, three-component domino reaction of aldehydes, enaminones, and malononnitrile. In this one-pot reaction, up to five new bonds were formed accompanied by generating the lactam group. This method has the advantages of short synthetic route, operational simplicity, increased safety for small-scale high-speed synthesis, and minimal environment impact.