A Nano-Combinatorial Library Strategy for the Discovery of Nanotubes with Reduced Protein-Binding, Cytotoxicity, and Immune Response

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• 作者：Hongyu Zhou ; Qingxin Mu ; Ningning Gao ; Aifeng Liu ; Yuehan Xing ; Sulian Gao ; Qiu Zhang ; Guangbo Qu ; Yuyan Chen ; Gang Liu ; Bin Zhang ; Bing Yan
• 刊名：Nano Letters
• 出版年：2008
• 出版时间：March 2008
• 年：2008
• 卷：8
• 期：3
• 页码：859 - 865
• 全文大小：2330K
• 年卷期：v.8,no.3(March 2008)
• ISSN：1530-6992

文摘

We have discovered functionalized multiwalled carbon nanotubes with reduced protein-binding, cytotoxicity, and immune response and the associated structure–activity relationships using in silico surface molecular diversity design, combinatorial library synthesis, and multiple biological screenings. Our results demonstrated the general utility of the nanocombinatorial library approach in nanomedicine and nanotoxicity research.