Asymmetric CuH-Catalyzed Hydrosilylations en Route to the C-9 Epimer of Amphidinoketide

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• 作者：Bruce H. Lipshutz ; Ching-Tien Lee ; Jeff M. Servesko
• 刊名：Organic Letters
• 出版年：2007
• 出版时间：November 8, 2007
• 年：2007
• 卷：9
• 期：23
• 页码：4713 - 4716
• 全文大小：79K
• 年卷期：v.9,no.23(November 8, 2007)
• ISSN：1523-7052

文摘

The C-9 diastereomer of amphidinoketide I has been synthesized. An asymmetric CuH-catalyzed hydrosilylation based on the Solvias nonracemicJosiphos-related ligand (R,S)-PPF-P(t-Bu)₂ was successfully used to introduce each of three stereocenters found in the target compound.