Detection of Breast Cancer Microcalcifications Using a Dual-modality SPECT/NIR Fluorescent Probe

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• 作者：Kumar R. Bhushan ; Preeti Misra ; Fangbing Liu ; Sanjeev Mathur ; Robert E. Lenkinski ; John V. Frangioni
• 刊名：Journal of the American Chemical Society
• 出版年：2008
• 出版时间：December 31, 2008
• 年：2008
• 卷：130
• 期：52
• 页码：17648-17649
• 全文大小：155K
• 年卷期：v.130,no.52(December 31, 2008)
• ISSN：1520-5126

文摘

Efficient chemical synthesis of a trifunctional, hydroxyapatite-binding molecule, which provides simultaneous in vivo imaging by NIR fluorescence and SPECT/CT has been described. Quantitation by SPECT provides the “gold standard” by which NIR fluorescence tomography of breast cancer microcalcifications can now be compared and optimized.