CuH-Catalyzed Enantioselective Intramolecular Reductive Aldol Reactions Generating Three New Contiguous Asymmetric Stereocenters

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• 作者：Bruce H. Lipshutz ; Benjamin Amorelli ; John B. Unger
• 刊名：Journal of the American Chemical Society
• 出版年：2008
• 出版时间：November 5, 2008
• 年：2008
• 卷：130
• 期：44
• 页码：14378-14379
• 全文大小：144K
• 年卷期：v.130,no.44(November 5, 2008)
• ISSN：1520-5126

文摘

Treatment of β,β-disubstituted-α,β-unsaturated ketones bearing a ketone residue with in situ generated, catalytic CuH ligated by a nonracemic ligand leads to three newly created adjacent chiral centers. Excellent deʼs and eeʼs are obtained for several examples studied.