Design and Synthesis of a G-Protein-Coupled Receptor Antagonist Library of Aryloxyalkanolamines Using a Polymer-Supported Acyclic Acetal Linker

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• 作者：Jacques Y. Roberge ; Lalgudi S. Harikrishnan ; Muthoni G. Kamau ; Zheming Ruan ; Katy Van Kirk ; Yalei Liu ; Christopher B. Cooper ; Michael A. Poss ; John K. Dickson ; ; Ashvinikumar V. Gavai ; Sam T. Chao ; Le
• 刊名：Journal of Combinatorial Chemistry
• 出版年：2009
• 出版时间：January 12, 2009
• 年：2009
• 卷：11
• 期：1
• 页码：72-82
• 全文大小：263K
• 年卷期：v.11,no.1(January 12, 2009)
• ISSN：1520-4774

文摘

A G-Protein-coupled receptor-targeted library of aryloxypropanolamines and aryloxybutanolamines was efficiently executed using a novel, polymer-supported acyclic acetal linker, producing compounds in good yields and purities.