Pestalazines and Pestalamides, Bioactive Metabolites from the Plant Pathogenic Fungus Pestalotiopsis theae

详细信息    查看全文

• 作者：Gang Ding ; Lihua Jiang ; Liangdong Guo ; Xulin Chen ; Hua Zhang ; Yongsheng Che
• 刊名：Journal of Natural Products
• 出版年：2008
• 出版时间：December 1, 2008
• 年：2008
• 卷：71
• 期：11
• 页码：1861-1865
• 全文大小：129K
• 年卷期：v.71,no.11(December 1, 2008)
• ISSN：1520-6025

文摘

Pestalazines A (1) and B (2), two new diketopiperazine heterodimers, and pestalamides A−C (3−5), three new amides, have been isolated from cultures of the plant pathogenic fungus Pestalotiopsis theae. The structures of these compounds were elucidated mainly by NMR spectroscopy. The absolute configurations of 1 and 2 were determined using Marfey’s method on their acid hydrolysates and by comparison of their CD spectra with that of a model compound. Compounds 1, 3, and 6 displayed inhibitory effects on HIV-1 replication in C8166 cells. Compound 3 also showed potent antifungal activity against Aspergillus fumigatus.