Phthalides from Pittosporum illicioides var. illicioides with Inhibitory Activity on Superoxide Generation and Elastase Release by Neutrophils

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• 作者：Tsung-Hsien Chou ; Ih-Sheng Chen ; Tsong-Long Hwang ; Tai-Chi Wang ; Tzong-Huei Lee ; Lin-Yang Cheng ; Ya-Chih Chang ; Jui-Ying Cho ; Jih-Jung Chen
• 刊名：Journal of Natural Products
• 出版年：2008
• 出版时间：October 24, 2008
• 年：2008
• 卷：71
• 期：10
• 页码：1692-1695
• 全文大小：135K
• 年卷期：v.71,no.10(October 24, 2008)
• ISSN：1520-6025

文摘

Six new phthalides, (S)-3-ethyl-7-hydroxy-6-methoxyphthalide (1), (S)-3-ethyl-7-hydroxy-5,6-dimethoxyphthalide (2), (S)-3-ethyl-5,6,7-trimethoxyphthalide (3), (R)-3-ethyl-7-hydroxy-6-methoxyphthalide (4), (Z)-3-ethylidene-7-hydroxy-6-methoxyphthalide (5), and (Z)-3-ethylidene-6,7-dimethoxyphthalide (6), have been isolated from the root of Pittosporum illicioides var. illicioides, together with seven known compounds. The structures of these new compounds were determined through spectroscopic and MS analyses. Compounds 1−4 exhibited inhibition (IC₅₀ ≤ 29.8 μM) of superoxide anion generation by human neutrophils in response to formyl-l-methionyl-l-leucyl-l-phenylalanine/cytochalasin B (fMLP/CB). Compounds 5 and 6 inhibited fMLP/CB-induced elastase release with IC₅₀ values of 38.6 ± 4.3 and 33.9 ± 3.9 μM, respectively.