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• 作者：Jing Sun ; Xuesi Chen ; Tiancheng Lu ; Shi Liu ; Huayu Tian ; Zhaopei Guo ; Xiabin Jing
• 刊名：Langmuir
• 出版年：2008
• 出版时间：September 16, 2008
• 年：2008
• 卷：24
• 期：18
• 页码：10099-10106
• 全文大小：282K
• 年卷期：v.24,no.18(September 16, 2008)
• ISSN：1520-5827

文摘

A novel biodegradable diblock copolymer, poly(l-cysteine)-b-poly(l-lactide) (PLC-b-PLLA), was synthesized by ring-opening polymerization (ROP) of N-carboxyanhydride of β-benzyloxycarbonyl-l-cysteine (ZLC-NCA) with amino-terminated poly(l-lactide) (NH₂-PLLA) as a macroinitiator in a convenient way. The diblock copolymer and its precursor were characterized by ¹H NMR, Fourier transform infrared (FT-IR), gel permeation chromatography (GPC), and X-ray photoelectron spectroscopy (XPS) measurements. The length of each block polymer could be tailored by molecular design and the ratios of feeding monomers. The cell adhesion and cell spread on the PZLC-b-PLLA and PLC-b-PLLA films were enhanced compared to those on pure PLA film. PLC-b-PLLA can self-assemble to form micelles in aqueous media. A pyrene probe is used to demonstrate the micelle formation of PLC-b-PLLA in aqueous solution. Due to the ease of disulfide exchange with thiols, the obtained micelles are reversible shell cross-linked (SCL) micelles. The morphology and size of the micelles are studied by dynamic light scattering (DLS) and environmental scanning electron microscopy (ESEM).