Preparation of Well-Defined Core−Shell Particles by Cu2+-Mediated Graft Copolymerization of Methyl Methacrylate from Bovine Serum Albumin

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• 作者：Chuanxin He ; Jianhong Liu ; Xiaodong Ye ; Laiyong Xie ; Qianling Zhang ; Xiangzhong Ren ; Guangzhao Zhang ; Chi Wu
• 刊名：Langmuir
• 出版年：2008
• 出版时间：October 7, 2008
• 年：2008
• 卷：24
• 期：19
• 页码：10717-10722
• 全文大小：240K
• 年卷期：v.24,no.19(October 7, 2008)
• ISSN：1520-5827

文摘

Small well-defined core−shell poly(methyl methacrylate)−bovine serum albumin (PMMA-BSA) particles have been prepared in a direct one-step graft copolymerization of MMA from BSA at 75 °C in water with a trace amount of Cu²⁺ (5 μM). Initially, BSA generates free radicals and acts as a multifunctional macroinitiator, which leads to the formation of an amphiphilic PMMA-BSA grafting copolymer. Such formed copolymer chains act as a polymeric stabilizer to promote further emulsion polymerization of MMA inside, resulting in surfactant-free stable core−shell particles, confirmed by a transmission electron microscopic (TEM) analysis. The PMMA-BSA copolymers as well as PMMA homopolymer inside the particles were isolated by Soxhlet extraction and characterized by Fourier transform infrared spectroscopy (FT-IR) and thermogravimetry (TG). The highest grafting efficiency was ∼80%. Effects of the reaction temperature, the MMA/BSA ratio, and the concentrations of Cu²⁺ and BSA on such core−shell particle formation have been systematically studied. Due to their inert PMMA core and biocompatible BSA shell, these small polymer particles are potentially useful in biomedical applications.