Concise Total Synthesis of (+)-Aspergillide B

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• 作者：Jian Liu ; Ke Xu ; Jinmei He ; Ling Zhang ; Xinfu Pan ; Xuegong She
• 刊名：Journal of Organic Chemistry
• 出版年：2009
• 出版时间：July 17, 2009
• 年：2009
• 卷：74
• 期：14
• 页码：5063-5066
• 全文大小：172K
• 年卷期：v.74,no.14(July 17, 2009)
• ISSN：1520-6904

文摘

An efficient total synthesis of (+)-aspergillide B has been achieved, which features the C-glycosylation reaction for constructing the 2,6-trans-substituted pyran core, a highly effective four-step sequence without purification to produce the key intermediate 13 and an advantegous E-selective Julia−Kocienski olefination on a highly elaborate substrate. The synthesis confirmed the revised structure of aspergillide B by Uenishi.