Novel Composite Drug Delivery System for Honokiol Delivery: Self-Assembled Poly(ethylene glycol)−Poly(ε-caprolactone)−Poly(ethylene glycol) Micelles in Thermosensitive Poly(ethylene g

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• 作者：ChangYang Gong ; Shuai Shi ; XiuHong Wang ; YuJun Wang ; ShaoZhi Fu ; PengWei Dong ; LiJuan Chen ; Xia Zhao ; YuQuan Wei ; ZhiYong Qian
• 刊名：Journal of Physical Chemistry B
• 出版年：2009
• 出版时间：July 30, 2009
• 年：2009
• 卷：113
• 期：30
• 页码：10183-10188
• 全文大小：255K
• 年卷期：v.113,no.30(July 30, 2009)
• ISSN：1520-5207

文摘

This study aims to develop a novel composite drug delivery system (CDDS) for hydrophobic honokiol delivery: honokiol loaded micelles in thermosensitive hydrogel (honokiol micelles/hydrogel) based on biodegradable poly(ethylene glycol)−poly(ε-caprolactone)−poly(ethylene glycol) (PEG−PCL−PEG, PECE) copolymers. In our work, we found that PECE copolymers with different molecular weight and PEG/PCL ratios could be administired to form micelles or thermosensitive hydrogel, respectively. Honokiol loaded PECE micelles (honokiol micelles) were prepared by self-assembly of biodegradable PECE copolymer (PEG₅₀₀₀−PCL₅₀₀₀−PEG₅₀₀₀) triggered by its amphiphilic characteristic assisted by ultrasonication without using any organic solvents and surfactants. Meanwhile, biodegradable and injectable thermosensitive PECE hydrogel (PEG₅₅₀−PCL₂₄₀₀−PEG₅₅₀) with a lower sol−gel transition temperature at around physiological temperature was also prepared successfully. Furthermore, the obtained honokiol micelles/hydrogel CDDS was a free-flowing sol at ambient temperature and became a nonflowing gel at body temperature. The cytotoxicity results showed that the CDDS was a safe carrier and the encapsulated honokiol retained its potent antitumor effect. In addition, the in vitro release profile demonstrated a significant difference between rapid release of free honokiol and much slower and sustained release of honokiol micelles/hydrogel. The results suggested that the CDDS might have great potential applications in cancer chemotherapy.