Development of an Open-Air and Robust Method for Large-Scale Palladium-Catalyzed Cyanation of Aryl Halides: The Use of i-PrOH to Prevent Catalyst Poisoning by Oxygen

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• 作者：Yunlai Ren ; Zhifei Liu ; Shebin He ; Shuang Zhao ; Jianji Wang ; Ruiqi Niu ; Weiping Yin
• 刊名：Organic Process Research & Development
• 出版年：2009
• 出版时间：July 17, 2009
• 年：2009
• 卷：13
• 期：4
• 页码：764-768
• 全文大小：156K
• 年卷期：v.13,no.4(July 17, 2009)
• ISSN：1520-586X

文摘

Palladium-catalyzed cyanation of aryl halides is an often capricious reaction and lacks robustness due to catalyst poisoning by oxygen. In this report, an open-air and robust method for large-scale cyanation was developed and the use of commercially available i-propanol as an additive was critical for achieving the open-air, robust and scaleable process. Under the protection by i-propanol, the catalyst life was significantly prolonged.