Enantioselective Synthesis of Chiral α-Aryl or α-Alkyl Substituted Ethylphosphonates via Rh-Catalyzed Asymmetric Hydrogenation with a P-Stereogenic BoPhoz-Type Ligand

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• 作者：Dao-Yong Wang ; Xiang-Ping Hu ; Jun Deng ; Sai-Bo Yu ; Zheng-Chao Duan ; Zhuo Zheng
• 刊名：Journal of Organic Chemistry
• 出版年：2009
• 出版时间：June 5, 2009
• 年：2009
• 卷：74
• 期：11
• 页码：4408-4410
• 全文大小：124K
• 年卷期：v.74,no.11(June 5, 2009)
• ISSN：1520-6904

文摘

An enantioselective synthesis of optically active 1-aryl or 1-alkyl substituted ethylphosphonates, based on the first Rh-catalyzed asymmetric hydrogenation of corresponding α,β-unsaturated precursors with a P-stereogenic BoPhoz-type ligand under the mild condition, was developed, in which a wide range of 1-aryl or 1-alkyl substituted ethylphosphonates were achieved in up to 98% ee.