Novel and Direct Transformation of Methyl Ketones or Carbinols to Primary Amides by Employing Aqueous Ammonia

详细信息    查看全文

• 作者：Liping Cao ; Jiaoyang Ding ; Meng Gao ; Zihua Wang ; Juan Li ; Anxin Wu
• 刊名：Organic Letters
• 出版年：2009
• 出版时间：September 3, 2009
• 年：2009
• 卷：11
• 期：17
• 页码：3810-3813
• 全文大小：171K
• 年卷期：v.11,no.17(September 3, 2009)
• ISSN：1523-7052

文摘

A novel and direct transformation of aryl, heteroaryl, vinyl, or ethynyl methyl ketones or carbinols to corresponding primary amides has been developed. An iodine-NH₃·H₂O system was proven to be efficient for this reaction and afforded the expected products with good yields in aqueous media. A tandem Lieben−Haller−Bauer reaction mechanism was involved in this type of reaction and is proposed for the first time.