Allium Chemistry: Synthesis of 1-[Alk(en)ylsulfinyl]propyl Alk(en)yl Disulfides (Cepaenes), Antithrombotic Flavorants from Homogenates of Onion (Allium cepa)

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• 作者：Eric Block ; Harsh Gulati ; David Putman ; Deyou Sha ; Niannian You ; and Shu-Hai Zhao
• 刊名：Journal of Agricultural and Food Chemistry
• 出版年：1997
• 出版时间：November 1997
• 年：1997
• 卷：45
• 期：11
• 页码：4414 - 4422
• 全文大小：257K
• 年卷期：v.45,no.11(November 1997)
• ISSN：1520-5118

文摘

A series of 1-[alk(en)ylsulfinyl]propylalk(en)yl disulfides (-sulfinyl disulfides) of structureRS(O)CHEtSSR', R, R' = Me, (E,Z)-MeCH=CH,n-Pr, and CH₂=CHCH₂, termedcepaenes, have beensynthesized by a variety of routes including oxidation of1-[alk(en)ylthio]propyl alk(en)yldisulfides,RSCHEtSSR', termed deoxycepaenes. The cepaenes are identical tocompounds isolated fromhomogenates of onion (Allium cepa) and tocompounds identified in these homogenates by liquidchromatography/mass spectrometry, while the deoxycepaenes are identicalto compounds found inAllium distilled oils and in other materials. Theantithrombotic activities for several cepaenes arereported.Keywords: Allium chemistry; onion (Allium cepa); a-sulfinyl disulfides;cepaenes; antithromboticcompounds