Antifungal Cyclopentenediones from Piper coruscans

详细信息    查看全文

• 作者：Xing-Cong Li ; Daneel Ferreira ; Melissa R. Jacob ; Qifeng Zhang ; Shabana I. Khan ; Hala N. ElSohly ; Dale G. Nagle ; Troy J. Smillie ; Ikhlas A. Khan ; Larry A. Walker ; and Alice M. Clark
• 刊名：Journal of the American Chemical Society
• 出版年：2004
• 出版时间：June 9, 2004
• 年：2004
• 卷：126
• 期：22
• 页码：6872 - 6873
• 全文大小：39K
• 年卷期：v.126,no.22(June 9, 2004)
• ISSN：1520-5126

文摘

Coruscanones A and B, two new antifungal cyclopentenedione derivatives, have been isolated from Piper coruscans and their structures elucidated by spectroscopic and chemical methods. Coruscanone A exhibits significant antifungal activity against Candida albicans and its azole-resistant strains and may serve as a template for a new class of antifungal agents.