Asymmetric 1,4-Hydrosilylations of ,-Unsaturated

详细信息    查看全文

• 作者：Bruce H. Lipshutz ; Jeff M. Servesko ; and Benjamin R. Taft
• 刊名：Journal of the American Chemical Society
• 出版年：2004
• 出版时间：July 14, 2004
• 年：2004
• 卷：126
• 期：27
• 页码：8352 - 8353
• 全文大小：72K
• 年卷期：v.126,no.27(July 14, 2004)
• ISSN：1520-5126

文摘

Complexing catalytic amounts of CuH with a nonracemic JOSIPHOS or SEGPHOS ligand, together with stoichiometric PMHS, leads to exceedingly efficient and highly enantioselective 1,4-reductions of ,-disubstituted enoates and lactones. An unprecedented substrate-to-ligand ratio of 7700:1 for this type of reaction is documented.