Asymmetric Hydrosilylation of Aryl Ketones Catalyzed by Copper Hydride Complexed by Nonracemic Biphenyl Bis-phosphine Ligands

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• 作者：Bruce H. Lipshutz ; Kevin Noson ; Will Chrisman ; and Asher Lower
• 刊名：Journal of the American Chemical Society
• 出版年：2003
• 出版时间：July 23, 2003
• 年：2003
• 卷：125
• 期：29
• 页码：8779 - 8789
• 全文大小：269K
• 年卷期：v.125,no.29(July 23, 2003)
• ISSN：1520-5126

文摘

When complexed by selected ligands in either the BIPHEP or the SEGPHOS series, CuH is anextremely reactive catalyst capable of effecting asymmetric hydrosilylations of aromatic ketones attemperatures between -50 and -78 C. Inexpensive silanes serve as stoichiometric sources of hydride.Substrate-to-ligand ratios exceeding 100,000:1 have been documented. The level of induction is usually inthe >90% ee category. The nature of the reagent has been investigated using spectroscopic and chemicalmeans, although its composition remains unclear.