Irregularities in the Effect of Potassium Phosphate in Ynamide Synthesis

详细信息    查看全文

• 作者：Karin Dooleweerdt ; Henrik Birkedal ; Thomas Ruhland ; Troels Skrydstrup
• 刊名：Journal of Organic Chemistry
• 出版年：2008
• 出版时间：December 5, 2008
• 年：2008
• 卷：73
• 期：23
• 页码：9447-9450
• 全文大小：230K
• 年卷期：v.73,no.23(December 5, 2008)
• ISSN：1520-6904

文摘

The yields of ynamides using Hsung′s second generation protocol depend substantially on the quality of K₃PO₄. Samples of K₃PO₄ from different suppliers were investigated by various techniques, revealing that the use of pure and anhydrous K₃PO₄ provides higher ynamide yields in comparison to samples contaminated with hydrates (K₃PO₄·1.5H₂O and K₃PO₄·7H₂O). With high quality K₃PO₄, a number of ynamides were synthesized in yields of 52−91%. In addition, we report that ynamides can undergo regioselective hydroamination with carbamates.