Bioactive Cembrane Diterpenoids of Anisomeles indica

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• 作者：Yu-Li Chen ; Yu-Hsuan Lan ; Pei-Wen Hsieh ; Chin-Chung Wu ; Shu-Li Chen ; Chiao-Ting Yen ; Fang-Rong Chang ; Wen-Chun Hung ; Yang-Chang Wu
• 刊名：Journal of Natural Products
• 出版年：2008
• 出版时间：July 2008
• 年：2008
• 卷：71
• 期：7
• 页码：1207-1212
• 全文大小：187K
• 年卷期：v.71,no.7(July 2008)
• ISSN：1520-6025

文摘

Five new cembrane-type diterpenoids with a trans-fused α-methylene-γ-lactone (1−5), a new flavonoid glucoside (6), and 17 known compounds were isolated from a methanol extract of Anisomeles indica. The structures of 1−6 were elucidated by spectroscopic analysis, and the absolute configuration of compound 1 was determined using the modified Mosher’s method. Compound 8 (4,5-epoxovatodiolide) exhibited cytotoxicity against a small panel of human cancer cell lines. Additionally, compounds 4 and 7 (ovatodiolide) exhibited selective antiplatelet aggregation activities toward collagen, while compounds 4, 5, and 8 showed inhibitory effects on antiplatelet aggregation induced by thrombin.