Pulsed Electrospray for Mass Spectrometry

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• 作者：Yu Lu ; Feng Zhou ; Wenqing Shui ; Liping Bian ; Yinlong Guo ; and Pengyuan Yang
• 刊名：Analytical Chemistry
• 出版年：2001
• 出版时间：October 1, 2001
• 年：2001
• 卷：73
• 期：19
• 页码：4748 - 4753
• 全文大小：173K
• 年卷期：v.73,no.19(October 1, 2001)
• ISSN：1520-6882

文摘

Pulsed electrospray has been developed and been reported for the first time. This new technique is based onthe principle of pulsed ion sources, combined with theconventional electrospray. The pulsed ion spray wasrealized by a homemade pulsed HV circuit and wasmonitored by a digital microscope and an oscilloscope.Results show that the pulsed ESI device can be operatedunder proper conditions for a clear on-and-off sprayprocess and that the device was kept in good electriccontact for electrospray when pulsed HV was on. A pulsedion current and pulsed mass spectra can be achieved withthis pulsed ESI device. Furthermore, it has been notedthat, under the same conditions (i.e., shape and size ofsprayer tip, distance from sprayer tip to sampling nozzle,and other parameters for mass spectrometer), stableelectrospray could be obtained for lower flow rates with apulsed spray device. This experimental fact indicates thepossible reduction in the total sample consumed couldbe realized by exploiting this novel design.