Pitucamycin: Structural Merger of a Phenoxazinone with an Epoxyquinone Antibiotic

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• 作者：Patrcia Bezerra Gomes ; Markus Nett ; Hans-Martin Dahse ; Christian Hertweck
• 刊名：Journal of Natural Products
• 出版年：2010
• 出版时间：September 24, 2010
• 年：2010
• 卷：73
• 期：9
• 页码：1461-1464
• 全文大小：171K
• 年卷期：v.73,no.9(September 24, 2010)
• ISSN：1520-6025

文摘

Chemical profiling of a Streptomyces griseus strain isolated from an old building with moisture damage led to the discovery of two novel phenoxazinones, chandrananimycin D (1) and pitucamycin (2), along with the known grixazone B (3). Pitucamycin represents an unprecedented hybrid molecule composed of a phenoxazinone and an enaminomycin-like epoxyquinone moiety.