Mineralization, Biodegradation, and Drug Release Behavior of Gelatin/Apatite Composite Microspheres for Bone Regeneration

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• 作者：Sander C. G. Leeuwenburgh ; Junichiro Jo ; Huanan Wang ; Masaya Yamamoto ; John A. Jansen ; Yasuhiko Tabata
• 刊名：Biomacromolecules
• 出版年：2010
• 出版时间：October 11, 2010
• 年：2010
• 卷：11
• 期：10
• 页码：2653-2659
• 全文大小：291K
• 年卷期：v.11,no.10(October 11, 2010)
• ISSN：1526-4602

文摘

Gelatin microspheres are well-known for their capacity to release growth factors in a controlled manner, but gelatin microspheres do not calcify in the absence of so-called bioactive substances that induce deposition of calcium phosphate (CaP) bone mineral. This study has investigated if CaP nanocrystals can be incorporated into gelatin microspheres to render these inert microspheres bioactive without compromising the drug releasing properties of gelatin microspheres. Incorporation of CaP nanocrystals into gelatin microspheres resulted into reduced biodegradation and drug release rates, whereas their calcifying capacity increased strongly compared to inert gelatin microspheres. The reduced drug release rate was correlated to the reduced degradation rate as caused by a physical cross-linking effect of CaP nanocrystals dispersed in the gelatin matrix. Consequently, these composite microspheres combine beneficial drug-releasing properties of organic gelatin with the calcifying capacity of a dispersed CaP phase.