Synthesis of β- and γ-Carbolinones via Pd-Catalyzed Direct Dehydrogenative Annulation (DDA) of Indole-carboxamides with Alkynes Using Air as the Oxidant

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• 作者：Zhuangzhi Shi ; Yuxin Cui ; Ning Jiao
• 刊名：Organic Letters
• 出版年：2010
• 出版时间：July 2, 2010
• 年：2010
• 卷：12
• 期：13
• 页码：2908-2911
• 全文大小：244K
• 年卷期：v.12,no.13(July 2, 2010)
• ISSN：1523-7052

文摘

A palladium-catalyzed direct dehydrogenative annulation (DDA) of indolecarboxamides with internal alkynes via C−H and N−H bond cleavage using air as the oxidant was developed. With this method, both β- and γ-carbolinones can be easily prepared under the mild conditions.